Super Antioxidant for Nutraceutical, Cosmeceutical and Therapeutics

Reactive oxygen species (ROS) are small, highly reactive, oxygen-containing molecules that are naturally generated in small amounts during the body’s metabolic reactions and can react with and damage complex cellular molecules such as fats, proteins, or DNA.

Alcohol promotes the generation of ROS and/or interferes with the body’s normal defense mechanisms against these compounds through numerous processes, particularly in the liver. For example, alcohol breakdown in the liver results in the formation of molecules whose further metabolism in the cell leads to ROS production. Alcohol also stimulates the activity of enzymes called cytochrome P450s, which contribute to ROS production. Further, alcohol can alter the levels of certain metals in the body, thereby facilitating ROS production. Finally, alcohol reduces the levels of agents that can eliminate ROS (i.e., antioxidants). The resulting state of the cell, known as oxidative stress, can lead to cell injury. ROS production and oxidative stress in liver cells play a central role in the development of alcoholic liver disease (ALD).

In addition to contributing to the development of ALD, ROS have been implicated in many other major diseases that plague humans. A partial listing of these conditions includes:

• The toxic effects of Oxygen itself (such as the oxidation of lipids and proteins, generation of mutations in the DNA, and destruction of cell membranes)
• Cardiovascular diseases
• Atherosclerosis
• Various types of cancer
• Diabetes
• Neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease
• Toxicity of heavy metals (e.g., iron)
• Radiation injury
• Vitamin deficiency
• Toxicity of certain medications
• Inflammation, such as the destruction of joints, the synovial fluid that lubricates joints and one of its components (i.e., hyaluronic acid), as well as activation of inflammation-promoting signaling molecules
• Toxic effects of tobacco smoke
• Emphysema
• Cataracts

Increasing evidence suggests that aging may be a consequence of the normal, long-term exposure to ROS and the accumulation of oxidized, damaged molecules within the cell—a process that could be likened to a lifetime of “rusting away.” Accordingly, the health benefits of administering antioxidants such as vitamins E and C or other compounds are the subject of much current research, and clinical trials employing antioxidants in the treatment of various conditions are under way.

For example, Oxis International has invented ERGOTHIONEINE - the super antioxidant for nutraceutical, cosmeceutical and therapeutics with potential applications in the treatment of neurodegenerative (Alzheimer and Parkinson’s), cardiovascular diseases, diabetes and other conditions.

ERGO is naturally occurring, water soluble, amino acid multifaceted antioxidant produced by microbes in the soil and most commonly found in (but not produced by) various species of mushrooms and grapes, meats and dairy products. However, it is not commercially practical to extract ERGO from these natural sources and it essentially impossible to ingest a diet that provides enough ERGO to take full advantage of its potential health benefits.  Humans and most animals typically have low levels of ERGO since the amount of ERGO in the diet is relatively small.

Oxis intellectual property for ERGO includes three patents and two patent pending applications that cover the synthesis of highly purified ERGO and the protective effect of ERGO on mitochondria and other pivotal body structures and functions. A number of peer reviewed scientific papers indicate that ERGO is one of the most potent, multifaceted biological compounds with both appreciable antioxidant, anti-inflammatory, neuroprotective and other protective properties.  ERGO acts by itself, or in combination with other natural compounds to improve the body’s own intrinsic defenses against oxidative stress.

The Brain Slip

The human brain is, arguably, the most complex construct in nature, with its billions of neurons and synapses, all working together to ensure that we are able to process outside stimuli, such as noises, sights, tastes, and so on. It also allows us to store, process and remember memories, and also to move each and every part of our bodies. But, when things go wrong, the effects can be difficult to cope with. Some of the more minor slips of the brain are the déjà vu and the “tip-of-the-tongue,” and they have puzzled experts ever since they were first reported.

Basically, tip-of-the-tongue refers to trying to remember a word, knowing you know, but simply not remembering it at one point. Naturally, minutes or hours later, it comes back to you, and you start wondering how was it that you couldn't remember it in the first place, given that it was so obvious. Deja vu is a more complex phenomenon, and refers to the instances when you find certain events, people or places familiar, even though you haven't been there before. You witness actions going on around you and keep saying, “I remember this,” even though it's the first time you've been there.

Two new studies have recently come out, and they attempt to shed some light on some of the most weird and interesting manifestations of our brain. Wellesley College in Massachusetts Psychologist Jennie Pyers believes that tip-of-the-tongue moments occur most often in bilingual people simply because similar-sounding words in two or more languages compete for attention inside the brain. “Often when we're having tip-of-the-tongue experiences, words that sound the same come to mind. There's a sense that you do know the first letter; there's a sense that you might know how many syllables it is,” she said, quoted by NewScientist.

On the other hand, one of the most interesting explanations for deja vu is the fact that the brain recognizes subtle cues that the subconscious mind has just processed moments earlier. It's a well-known fact that the subconscious mind is aware of everything around us before we are, a fact that has been demonstrated in multiple functional Magnetic Resonance Imaging (fMRI) tests, where the parts of the brain were seen lighting up before the conscious mind became aware of a decision.

However, the explanation does not account for the fact that some people experiencing deja vu report feeling familiar emotions and states of mind, alongside familiarity with individuals they have never seen before and unique situations that never repeat themselves again. It's hard even for researchers to determine if déjà vu is a flaw of the brain, or if it's something else. And the possibilities may be too tantalizing for scientists to even think about considering.

How to Wake Up Looking Younger

Do you know what nursing is? The World Health Organization developed a very clear definition about nursing:

The mission of nursing in society is to help individuals, families and groups to determine and achieve their physical, mental and social potential, and to do so within the challenging context of the environment in which they live and work. This requires nurses to develop and perform functions that relate to the promotion and maintenance of health as well as to the prevention of ill health.

Nursing also includes the planning and implementation of care during illness and rehabilitation, and encompasses the physical, mental and social aspects of life as they affect health, illness, disability and dying. Nursing is the provision of care for individuals, families and groups throughout the entire life-span – from conception to death. Nursing is both an art and a science that requires the understanding and application of the knowledge and skills specific to the discipline. It also draws on knowledge and techniques derived from the humanities and the physical, social, medical and biological sciences.

Wow, what a remarkable profession! No wonder there are so many joyful experience in that field. Even better there is a clinical nursing site called scrubs, which specially dedicated to each of you, the nurse all over the world.

Scrubs is the one and only site that's 100 percent about you, nurse — personally and professionally — and the very specific joys and challenges you face because of the noble career you chose. So, on this site you'll not only find career advice and inspiring stories, but beauty and fashion tips as well as lots of ideas on making your downtime as relaxing as your work life is demanding.

One of the most interesting beauty and fashion tips is how to wake up looking younger, delivered by Anita Bruzzese. With the following five quick tweaks to your daily regimen (and the help of a few terrific and highly affordable products), you can wake up looking refreshed and, yes, younger! Before surrendering to slumber each night, be sure to take these steps:

1. Get clean. Never, never, never go to bed still wearing makeup, even if you worked a double shift or are so tired after a night working the ER that you don’t even remember your name. Wearing makeup to bed clogs pores, letting toxins penetrate more deeply. Cleansing cloths from Oil of Olay and Ponds make this task super easy. Use and throw away!
2. Moisturize. As we get older, our skin needs even more pampering. Once your face is clean, it’s better able to absorb a moisturizer. Try one that contains retinoids, a form of vitamin A. You can get a prescription-strength product from your doctor or try a drugstore brand like RoC Deep Wrinkle night cream. These products cause sun sensitivity, which is why it’s ideal to use them at night. You don’t really need a different cream for under the eyes; just make sure you apply eye cream with a light hand because that skin is often thinner and more sensitive. Aquaphor can be used to take off makeup and give you the added benefit of moisturizing the eye area.
3. Sleep right. Even though you may want to fall face down on the mattress after dealing with demanding doctors and needy patients all day, it's much better for your face if you sleep on your back. Sleeping on one side too much—or on your stomach—can lead to more wrinkles. To avoid morning eye puffiness when fluid collects in that area, either raise the head of your bed several inches or sleep on a couple of pillows.
4. Be kissable. As we age, our lips often become dry and lined. When brushing your teeth, give your lips a scrub, pat dry, then apply a lip treatment like Carmex.
5. Tame stray hairs. Nothing makes you look older than ungroomed eyebrows or those chin hairs that would make a billy goat proud. Plucking and depilatories often cause redness, so grooming at night lets your skin calm down by morning.

Mesothelioma: Lung Cancer Associated with Asbestos Exposure

Mesothelioma has been such a rare disease, or one recognized so infrequently, that it has not been coded as a separate cause of death and has been seriously underestimated in mortality statistics. The age-adjusted incidence of pleural and peritoneal mesothelioma in the United States has been estimated at 14.2 per million per year, with almost a three-fold increase for pleural mesothelioma in Caucasian males between 1973 and 1984. The male-female ratio is about 4:1, and 80% arise from the pleura. Cases tend to be clustered in areas of asbestos product plants and shipbuilding facilities. Similar trends have been reported in other industrialized countries, such as England.

In autopsy studies, the frequency of malignant mesothelioma varies from 0.02 to 0.7%, with a rate of 0.2% in the largest series. In most hospital series, the pleura is more often involved than the peritoneum, with a predominance of the right side over the left (60:40). In some epidemiologic studies monitoring cohorts of asbestos workers, however, the peritoneal form is more common than the pleural.

The mean age of patients is approximately 60 years, but the disease can occur at any age, including in childhood. In a review of 80 children with a diagnosis of malignant mesothelioma, the mean age was 9.7 years, and 59% were male. Only 2 children were noted to have a history of possible asbestos exposure, 1 had received radiotherapy for Wilms’ tumor, and 1 had been exposed to isoniazid in utero.

A unique feature of mesothelioma is its strong relationship with asbestos exposure, which has recently led to great public concern in view of the ubiquitous presence of that mineral.  Despite the fact that the dangers of asbestos exposure have been known since the 1920s, this fire resistant, lung incinerating material is still used in production and construction today. Granted, the government came forward in 1980 and placed a few new rules and regulations in place to help minimize the effects of too much asbestos exposure, but Mesothelioma victims will tell you that it was simply a case of a little too little and a little too late.

Public awareness of Mesothelioma has risen ten fold over the past ten to fifteen years, making it even more detrimental that companies today are still utilizing this material. There is very little payoff which would entice anyone with the necessary education into working in conditions that are likely to cause Mesothelioma.

People do not have the information they need regarding asbestos exposure and the threat that Mesothelioma presents in their life. Withholding such information leaves people at a serious disadvantage when it comes to making educated decisions about their health as it pertains to the work environment. It is fair to say that people do not typically willingly expose themselves to high levels of asbestos knowing the threat of Mesothelioma is very real and very ugly.

Mesothelioma settlements reflect the company's acknowledgement as to their culpability in these cases. While there is the perpetual excuse that companies tend to settle a Mesothelioma lawsuit to avoid negative press, there is much more truth to the notion that a company is much more willing to shell out to a Mesothelioma victim they are readily convinced contracted the disease while working for their company than they are to give hand outs to people they believe did not get sick working for them. A fight is only worth fighting when you believe you can win.

Not every case of Mesothelioma is one that will end up in settlement or a Mesothelioma lawsuit. A competent Mesothelioma Lawyer will honestly tell you that not every case of Mesothelioma is able to make it to court or settlement.

Hormonal Acne Therapy

Do you know who Chyler Leigh is? I am very sure that most of you could not forget her great contribution on Grey’s anatomy TV series. All right, what about this one: do you know what medication she choose to cure acne on her pregnancy? I tell you what, she take Beaute de Maman as the primary solution for her mom-to-be hormonal changed effects.

Anyway, what is acne? Acne is a disorder resulting from the action of hormones and other substances on the skin’s oil glands (sebaceous glands) and hair follicles. These factors lead to plugged pores and outbreaks of lesions commonly called pimples or zits. Acne lesions usually occur on the face, neck, back, chest, and shoulders. Although acne is usually not a serious health threat, it can be a source of significant emotional distress. Severe acne can lead to permanent scarring.

Did you know that there are many different types of acne? Pretty much all of us know about teenage acne. A lot of us are also aware of adult acne. More than a few of us are likewise aware of seasonal acne, even if we have only heard about it on commercials. However, what do you know about hormonal acne? Unfortunately, of all the different types of acne, this seems to be the one talked about the least. This is actually literally unfortunate, because with no one talking about it, it can be difficult to look for acne treatments which will be helpful in dealing with it. Very few types of acne medicine are designed to deal with the specific signs and symptoms of different types of acne. More often, most products just deal with general things, which generally do not provide long term help. Thus, it is even more important for you to understand all you can about your specific type of acne. Only then can you start considering different acne treatments. You have to be particularly careful with hormonal acne because, like say, so little is known about it.

The exact cause of acne is unknown, but doctors believe it results from several related factors. One important factor is an increase in hormones called androgens (male sex hormones). These increase in both boys and girls during puberty and cause the sebaceous glands to enlarge and make more sebum. Hormonal changes related to pregnancy or starting or stopping birth control pills can also cause acne.

Another factor is heredity or genetics. Researchers believe that the tendency to develop acne can be inherited from parents. For example, studies have shown that many school-age boys with acne have a family history of the disorder. Certain drugs, including androgens and lithium, are known to cause acne. Greasy cosmetics may alter the cells of the follicles and make them stick together, producing a plug.

So, if you looking for a hormonal acne therapy, why do not you follow the Hollywood celebrity smart choice’s? Even better, you can order now online.

Acne Hormones Pregnancy

Do you know Chyler Leigh? I am very sure that most of you could not forget her great contribution on Grey’s anatomy TV series. All right, what about this one: do you know what medication she choose to cure acne on her pregnancy? I tell you what, she take Beaute de Maman as the primary solution for her mom-to-be hormonal changed effects.

Anyway, what is acne? Acne is a disorder resulting from the action of hormones and other substances on the skin’s oil glands (sebaceous glands) and hair follicles. These factors lead to plugged pores and outbreaks of lesions commonly called pimples or zits. Acne lesions usually occur on the face, neck, back, chest, and shoulders. Although acne is usually not a serious health threat, it can be a source of significant emotional distress.  Severe acne can lead to permanent scarring.

The exact cause of acne is unknown, but doctors believe it results from several related factors. One important factor is an increase in hormones called androgens (male sex hormones). These increase in both boys and girls during puberty and cause the sebaceous glands to enlarge and make more sebum. Hormonal changes related to pregnancy or starting or stopping birth control pills can also cause acne.

Another factor is heredity or genetics. Researchers believe that the tendency to develop acne can be inherited from parents. For example, studies have shown that many school-age boys with acne have a family history of the disorder. Certain drugs, including androgens and lithium, are known to cause acne. Greasy cosmetics may alter the cells of the follicles and make them stick together, producing a plug.

So, if you looking for an acne therapy, my suggestion on this case, why do not you follow the hollywood celebrity smart choice? Even better, You can order now online.

Medicine allergy

Hello everyone. i am allergic to prochlorperazine. today i did my research and this is what i got. (i nearly cried reading some parts because they were trueeeeeeeeeee. and im going to wake my mom up now to tell her these things.)

Prochlorperazine (Stemetil)

In higher doses it is used in the treatment of psychiatric illnesses. In lower doses it is used in the management of nausea and vomiting.

Prochlorperazine works by blocking dopamine receptors in the brain. Dopamine is a natural compound called a neurotransmitter, and is involved in transmitting messages between brain cells. Dopamine is a neurotransmitter known to be involved in regulating mood and behaviour, amongst other things.

Prochlorperazine also affects dopamine receptors in an area of the brain that controls nausea and vomiting. Vomiting is controlled by an area of the brain called the vomiting centre. The vomiting centre is responsible for causing feelings of sickness (nausea) and for the vomiting reflex. It is activated when it receives nerve messages from another area of the brain called the chemoreceptor trigger zone (CTZ) and when it receives nerve messages from the gut.

Prochlorperazine controls nausea and vomiting by blocking dopamine receptors found in the CTZ. This stops the CTZ from sending the messages to the vomiting centre that would otherwise cause nausea and vomiting.

In adults, Stemetil is used for the conditions below.

Psychotic illness such as schizophrenia.

Acute mania.

Short-term treatment of severe anxiety.

Treatment and prevention of nausea and vomiting.

Relieving nausea, vomiting and attacks of dizziness or spinning sensations (vertigo) associated with Meniere's disease and other inner ear disorders.

Warnings:

This medicine may cause drowsiness. If affected do not drive or operate machinery. Alcohol should be avoided because it can make drowsiness worse.

This medicine can occasionally cause your blood pressure to drop when you move from a lying down or sitting position to sitting or standing, especially when you first start taking the medicine. This may make you feel dizzy or unsteady. To avoid this try getting up slowly. If you do feel dizzy, sit or lie down until the symptoms pass.

This medicine may make your skin more sensitive to sunlight than it usually is, so you should avoid exposing your skin to direct sunlight or sunlamps until you know how your skin reacts. If you can't avoid strong sunlight you should use a sunscreen lotion or make sure your skin is protected with clothing.

If you have been taking high doses of this medicine for a long time, for example to treat schizophrenia, you should not suddenly stop taking it unless your doctor tells you to, even if you feel better and think you don't need it any more. This is because the medicine controls the symptoms of the illness but doesn't actually cure it. This means that if you suddenly stop treatment your symptoms could come back. Stopping the medicine suddenly may also rarely cause withdrawal symptoms such as nausea, vomiting, difficulty sleeping or tremor. When treatment with this medicine is stopped, it should be done gradually, following the instructions given by your doctor.

This medicine may rarely cause a decrease in the normal amounts of white blood cells in the blood. For this reason, if you are taking high doses of this medicine for a long time your doctor may want you to have regular blood tests to check the levels of blood cells in your blood. You should consult your doctor immediately if you experience any of the following symptoms while taking this medicine, as they may indicate a problem with your blood cells: unexplained sore throat, mouth ulcers, infections, high temperature (fever) or general illness.

Consult your doctor immediately if you experience the following symptoms while taking this medicine: high temperature (fever), pale complexion, sweating, muscle stiffness, fast heartbeat and decreased consciousness. These symptoms may be due to a rare but serious side effect of this type of medicine, known as the neuroleptic malignant syndrome, and your treatment may need to be stopped.

Use with caution in

Elderly people.

Decreased kidney function.

Decreased liver function.

Heart disease.

Slow heart rate (bradycardia).

People with a personal or family history of an abnormal heart rhythm seen on a heart monitoring trace (ECG) as a 'prolonged QT interval'.

Low levels of potassium, calcium or magnesium in the blood (hypokalaemia, hypocalcaemia or hypomagnesaemia).

Malnutrition.

Dehydration.

Alcohol abuse.

Underactive thyroid gland (hypothyroidism).

Tumour of the adrenal gland (phaeochromocytoma).

Enlarged prostate gland (prostatic hypertrophy).

Parkinson's disease.

Abnormal muscle weakness (myasthenia gravis).

History of seizures (fits) eg epilepsy.

People with risk factors for having a stroke.

History of closed angle glaucoma.

History of a drop in the normal number of white blood cells in the blood.

Allergy to other phenothiazine medicines, eg chlorpromazine, trifluoperazine.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.

Drowsiness.

Dry mouth.

Difficulty sleeping (insomnia).

Skin rashes.

Stuffy nose.

A drop in blood pressure that occurs when moving from a lying down or sitting position to sitting or standing, which results in dizziness and lightheadedness (postural hypotension).

Abnormal movements of the hands, legs, face, neck and tongue, eg shakiness, twitching, rigidity.

Anxiety, restlessness and agitation (akathisia).

Rhythmical involuntary movements of the tongue, face, mouth and jaw, which may sometimes be accompanied by involuntary movements of the arms and legs (tardive dyskinesia).

Increased sensitivity of the skin to UV light (photosensitivity).

Interference with the body's temperature regulation (this is more common in elderly people and can cause heat stroke in very hot weather or hypothermia in very cold weather).

Decrease in the numbers of a type of white blood cell (neutrophil) in the blood (neutropenia).

Sudden severe deficiency in the number of white blood cells in the blood (agranulocytosis).

Abnormal heart beats (arrhythmias).

Yellowing of the skin and eyes (jaundice).

High blood prolactin (milk producing hormone) level (hyperprolactinaemia). Rarely this may lead to symptoms such as breast enlargement or production of milk.

Impotence.

Changes in menstrual periods.

There may be an increase in side effects such as dry mouth, constipation, confusion or heat stroke (in hot and humid conditions) if prochlorperazine is taken with other medicines that have anticholinergic effects, such as the following:

anticholinergic medicines for Parkinson's symptoms, eg procyclidine

antihistamines, eg brompheniramine, chlorphenamine

antispasmodic medicines, eg hyoscine

medicines for urinary incontinence, eg oxybutynin, flavoxate, tolterodine, propiverine, trospium

muscle relaxants, eg baclofen

MAOI antidepressants, eg phenelzine

tricyclic antidepressants, eg amitriptyline

other antipsychotic medicines

other antisickness medicines, eg promethazine, meclozine, cyclizine.

Epilepsy.

Epileptic attacks happen when an abnormal electrical discharge occurs in the brain, disturbing its normal function. The type of seizure depends upon where this takes place, and how much of the brain is affected. During an attack, these discharges may cause:

twitching of the muscles

abnormal sensations (eg tingling on one side of the body or awareness of a strange taste or smell)

emotional symptoms such as fear or 'deja vu '

loss of consciousness.

Flickering lights, such as strobe lights in nightclubs, can trigger seizures in some people. If this is the case, clubs with strobes are best avoided. It is also sensible to avoid playing computer games for long periods of time as the flickering screen has been associated with seizures in some susceptible people with epilepsy.

Glaucoma.

Glaucoma is not one disorder but a range of conditions in which the pressure inside the eye becomes too high. This results in damage to the optic nerve at the back of the eye which can lead to loss of vision if left untreated. Glaucoma is one of the most common causes of blindness worldwide.